IPR034362
PHIP1, RNA recognition motif 2
InterPro entry
Short name | PHIP1_RRM2 |
Overlapping homologous superfamilies | |
domain relationships |
Description
This entry represents the RNA recognition motif 2 (RRM2) of PHIP1. A. thaliana PHIP1 and its homologues represent a novel class of plant-specific RNA-binding proteins that may play a unique role in the polarized mRNA transport to the vicinity of the cell plate
[1]. PHIP1 is a peripheral membrane protein and is localized at the cell plate during cytokinesis in plants. In addition to phragmoplastin, PHIP1 interacts with two Arabidopsis small GTP-binding proteins, Rop1 and Ran2. However, PHIP1 interacted only with the GTP-bound form of Rop1 but not the GDP-bound form. It also binds specifically to Ran2 mRNA
[2]. This group of proteins consist of multiple functional domains, including a lysine-rich domain (KRD domain) that contains three nuclear localization motifs (KKKR/NK), two RNA recognition motifs (RRMs), and three CCHC-type zinc fingers.
References
1.A novel RNA-binding protein associated with cell plate formation. Ma L, Xie B, Hong Z, Verma DP, Zhang Z. Plant Physiol. 148, 223-34, (2008). View articlePMID: 18621982
2.Perinuclear and nuclear envelope localizations of Arabidopsis Ran proteins. Ma L, Hong Z, Zhang Z. Plant Cell Rep. 26, 1373-82, (2007). View articlePMID: 17530257
Contributing Member Database Entry
- CDD:cd12272