D
IPR034659

Atypical protein kinase C, catalytic domain

InterPro entry
Short nameAtypical_PKC
Overlapping
homologous
superfamilies
 

Description

PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their N-terminal regulatory domain
[12, 7]
. Atypical protein kinases C (aPKCs) have a PB1 and an atypical C1 domain, which only accepts phosphatidylserine
[11]
.

In mammals there are two aPKC isoforms, zeta and iota/lambda (iota is the human orthologue and lambda the mouse orthologue)
[10]
. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation
[1, 9]
. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes
[6, 3]
.

This entry consists mainly of invertebrate aPKCs. In Drosophila, aPKC is also involved in polarity maintenance, cytoskeletal regulation and cell cycle progression, and proliferation
[2, 1, 4, 8, 5]
.

References

1.aPKC controls microtubule organization to balance adherens junction symmetry and planar polarity during development. Harris TJ, Peifer M. Dev. Cell 12, 727-38, (2007). View articlePMID: 17488624

2.Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia. Rolls MM, Albertson R, Shih HP, Lee CY, Doe CQ. J. Cell Biol. 163, 1089-98, (2003). View articlePMID: 14657233

3.Atypical protein kinase C in insulin action and insulin resistance. Farese RV, Sajan MP, Standaert ML. Biochem. Soc. Trans. 33, 350-3, (2005). View articlePMID: 15787604

4.Drosophila aPKC is required for mitotic spindle orientation during symmetric division of epithelial cells. Guilgur LG, Prudencio P, Ferreira T, Pimenta-Marques AR, Martinho RG. Development 139, 503-13, (2012). View articlePMID: 22223679

5.Dap160/intersectin binds and activates aPKC to regulate cell polarity and cell cycle progression. Chabu C, Doe CQ. Development 135, 2739-46, (2008). View articlePMID: 18614576

6.Atypical protein kinase C in glucose metabolism. Liu XJ, He AB, Chang YS, Fang FD. Cell. Signal. 18, 2071-6, (2006). View articlePMID: 16787739

7.Emerging and diverse roles of protein kinase C in immune cell signalling. Tan SL, Parker PJ. Biochem. J. 376, 545-52, (2003). View articlePMID: 14570590

8.A bidirectional antagonism between aPKC and Yurt regulates epithelial cell polarity. Gamblin CL, Hardy EJ, Chartier FJ, Bisson N, Laprise P. J. Cell Biol. 204, 487-95, (2014). View articlePMID: 24515345

9.Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation. Lee CY, Robinson KJ, Doe CQ. Nature 439, 594-8, (2006). View articlePMID: 16357871

10.Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells. Selbie LA, Schmitz-Peiffer C, Sheng Y, Biden TJ. J. Biol. Chem. 268, 24296-302, (1993). PMID: 8226978

11.Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif. Messerschmidt A, Macieira S, Velarde M, Badeker M, Benda C, Jestel A, Brandstetter H, Neuefeind T, Blaesse M. J. Mol. Biol. 352, 918-31, (2005). View articlePMID: 16125198

12.Protein kinase C and lipid signaling for sustained cellular responses. Nishizuka Y. FASEB J. 9, 484-96, (1995). PMID: 7737456

GO terms

Cross References

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