D
IPR034914

HuB, RNA recognition motif 3

InterPro entry
Short nameHuB_RRM3
Overlapping
homologous
superfamilies
 
domain relationships

Description

This entry represents the RNA recognition motif 3 (RRM3) of HuB.

HuB (also known as ELAV-like protein 2 or Hel-N1) is one of the neuronal members of the Hu family
[1]
. The neuronal Hu proteins play important roles in neuronal differentiation, plasticity and memory. HuB is also expressed in gonads. It is up-regulated during neuronal differentiation of embryonic carcinoma P19 cells
[2]
. Like other Hu proteins, HuB contains three RNA recognition motifs (RRMs). RRM1 and RRM2 may cooperate in binding to an AU-rich RNA element (ARE). RRM3 may help to maintain the stability of the RNA-protein complex, and might also bind to poly(A) tails or be involved in protein-protein interactions
[3]
.

References

1.A conserved family of elav-like genes in vertebrates. Good PJ. Proc. Natl. Acad. Sci. U.S.A. 92, 4557-61, (1995). View articlePMID: 7753842

2.Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation. Gao FB, Keene JD. J. Cell. Sci. 109 ( Pt 3), 579-89, (1996). PMID: 8907704

3.Diverse molecular functions of Hu proteins. Hinman MN, Lou H. Cell. Mol. Life Sci. 65, 3168-81, (2008). View articlePMID: 18581050

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