D
IPR034985

hnRPLL, RNA recognition motif 1

InterPro entry
Short namehnRPLL_RRM1
Overlapping
homologous
superfamilies
 
domain relationships

Description

This entry represents the RNA recognition motif 1 (RRM1) of hnRNP-LL.

hnRNP-LL plays a critical and unique role in the signal-induced regulation of CD45 and acts as a global regulator of alternative splicing in activated T cells
[1, 2]
. It is closely related in domain structure and sequence to heterogeneous nuclear ribonucleoprotein L (hnRNP-L), which is an abundant nuclear, multifunctional RNA-binding protein with three RNA-recognition motifs (RRMs).

References

1.A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4. Topp JD, Jackson J, Melton AA, Lynch KW. RNA 14, 2038-49, (2008). View articlePMID: 18719244

2.Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL. Oberdoerffer S, Moita LF, Neems D, Freitas RP, Hacohen N, Rao A. Science 321, 686-91, (2008). View articlePMID: 18669861

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