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IPR035965

PAS domain superfamily

InterPro entry
Short namePAS-like_dom_sf
Overlapping entries
 
PAS domain (IPR000014)
PAS fold-2 (IPR013654)
PAS fold-3 (IPR013655)
PAS fold-4 (IPR013656)

Description

PAS domains are involved in many signalling proteins where they are used as a signal sensor domain
[2]
. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. The PAS domain was named after three proteins that it occurs in:


 * Per- period circadian protein
 * Arnt- Ah receptor nuclear translocator protein
 * Sim- single-minded protein.


PAS domains are often associated with PAC domains
IPR001610
. It appears that these domains are directly linked, and that together they form the conserved 3D PAS fold. The division between the PAS and PAC domains is caused by major differences in sequences in the region connecting these two motifs
[1]
. In human PAS kinase, this region has been shown to be very flexible, and adopts different conformations depending on the bound ligand
[4]
. Probably the most surprising identification of a PAS domain was that in EAG-like K-channels
[3]
.

References

1.The PAS fold. A redefinition of the PAS domain based upon structural prediction. Hefti MH, Francoijs KJ, de Vries SC, Dixon R, Vervoort J. Eur. J. Biochem. 271, 1198-208, (2004). View articlePMID: 15009198

2.PAS domains: internal sensors of oxygen, redox potential, and light. Taylor BL, Zhulin IB. Microbiol. Mol. Biol. Rev. 63, 479-506, (1999). View articlePMID: 10357859

3.PAS domain S-boxes in Archaea, Bacteria and sensors for oxygen and redox. Zhulin IB, Taylor BL, Dixon R. Trends Biochem. Sci. 22, 331-3, (1997). View articlePMID: 9301332

4.Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation. Amezcua CA, Harper SM, Rutter J, Gardner KH. Structure 10, 1349-61, (2002). View articlePMID: 12377121

Cross References

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