H
IPR036013

Band 7/SPFH domain superfamily

InterPro entry
Short nameBand_7/SPFH_dom_sf
Overlapping entries
 
Band 7 domain (IPR001107)
Prohibitin (IPR000163)

Description

The band-7 protein family comprises a diverse set of membrane-bound proteins characterised by the presence of a conserved domain, the band-7 domain, also known as SPFH or PHB domain
[3]
. The exact function of the band-7 domain is not known, but examples from animal and bacterial stomatin-type proteins demonstrate binding to lipids and the ability to assemble into membrane-bound oligomers that form putative scaffolds
[2]
. A variety of proteins belong to this family. These include the prohibitins, cytoplasmic anti-proliferative proteins and stomatin, an erythrocyte membrane protein. Bacterial HflC protein also belongs to this family.

Note: Band 4.1 and Band 7 proteins refer to human erythrocyte membrane proteins separated by SDS polyacrylamide gels and stained with coomassie blue
[1]
.

References

1.Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. Fairbanks G, Steck TL, Wallach DF. Biochemistry 10, 2606-17, (1971). View articlePMID: 4326772

2.Mitochondrial Band-7 family proteins: scaffolds for respiratory chain assembly? Gehl B, Sweetlove LJ. Front Plant Sci 5, 141, (2014). View articlePMID: 24782879

3.The SPFH domain: implicated in regulating targeted protein turnover in stomatins and other membrane-associated proteins. Tavernarakis N, Driscoll M, Kyrpides NC. Trends Biochem. Sci. 24, 425-7, (1999). View articlePMID: 10542406

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