H
IPR036025

tRNA-splicing ligase RtcB-like superfamily

InterPro entry
Short nameRtcB-like_sf
Overlapping entries
 

Description

RctB is a RNA ligase that mediates the joining of broken tRNA-like stem-loop structures in case of tRNA damage. It probably participates to tRNA restriction-repair by ligating broken tRNA-like stem-loop structures with 2',3'-cyclic phosphate and 5'-OH ends to form a splice junction with a 2'-OH, 3',5'-phosphodiester
[1, 5, 3, 4]
. In worms, this protein has as a neuroprotective role in the age-dependent degeneration of dopamine neurons
[2]
.

References

1.RtcB is the RNA ligase component of an Escherichia coli RNA repair operon. Tanaka N, Shuman S. J. Biol. Chem. 286, 7727-31, (2011). View articlePMID: 21224389

2.RTCB-1 mediates neuroprotection via XBP-1 mRNA splicing in the unfolded protein response pathway. Ray A, Zhang S, Rentas C, Caldwell KA, Caldwell GA. J Neurosci 34, 16076-85, (2014). PMID: 25429148

3.tRNA ligase catalyzes the GTP-dependent ligation of RNA with 3'-phosphate and 5'-hydroxyl termini. Desai KK, Raines RT. Biochemistry 51, 1333-5, (2012). PMID: 22320833

4.Structural and mechanistic insights into guanylylation of RNA-splicing ligase RtcB joining RNA between 3'-terminal phosphate and 5'-OH. Englert M, Xia S, Okada C, Nakamura A, Tanavde V, Yao M, Eom SH, Konigsberg WH, Soll D, Wang J. Proc. Natl. Acad. Sci. U.S.A. 109, 15235-40, (2012). View articlePMID: 22949672

5.The RtcB RNA ligase is an essential component of the metazoan unfolded protein response. Kosmaczewski SG, Edwards TJ, Han SM, Eckwahl MJ, Meyer BI, Peach S, Hesselberth JR, Wolin SL, Hammarlund M. EMBO Rep 15, 1278-85, (2014). PMID: 25366321

GO terms

biological process

cellular component

  • None

Cross References

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