H
IPR036409

Class II aldolase/adducin N-terminal domain superfamily

InterPro entry
Short nameAldolase_II/adducin_N_sf
Overlapping entries
 

Description

This entry represents the α/β/α domain found in class II aldolases and in adducin (usually at the N terminus of adducin). Proteins containing this domain include: rhamnulose-1-phosphate aldolase (
4.1.2.19
), L-fuculose phosphate aldolase (
4.1.2.17
)
[1, 3]
that is involved in the third step in fucose metabolism, L-ribulose- 5-phosphate 4-epimerase (
5.1.3.4
) involved in the third step of L-arabinose catabolism, a probable sugar isomerase SgbE and the metazoan adducins, which have not been ascribed any enzymatic function but which play a role in cell membrane cytoskeleton organisation
[2]
. It also includes ribulose-1-phosphate aldolase that catalyses the cleavage of ribulose 1-phosphate to dihydroxyacetone phosphate and glycolaldehyde
[4]
.

This entry also includes the methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway. This pathway allows methylthioadenosine, left over from polyamine biosynthesis, to be recycled to methionine.

References

1.The spatial structure of the class II L-fuculose-1-phosphate aldolase from Escherichia coli. Dreyer MK, Schulz GE. J. Mol. Biol. 231, 549-53, (1993). View articlePMID: 8515438

2.Primary structure and domain organization of human alpha and beta adducin. Joshi R, Gilligan DM, Otto E, McLaughlin T, Bennett V. J. Cell Biol. 115, 665-75, (1991). View articlePMID: 1840603

3.Catalytic mechanism of the metal-dependent fuculose aldolase from Escherichia coli as derived from the structure. Dreyer MK, Schulz GE. J. Mol. Biol. 259, 458-66, (1996). View articlePMID: 8676381

4.A non-carboxylating pentose bisphosphate pathway in halophilic archaea. Sato T, Utashima SH, Yoshii Y, Hirata K, Kanda S, Onoda Y, Jin JQ, Xiao S, Minami R, Fukushima H, Noguchi A, Manabe Y, Fukase K, Atomi H. Commun Biol 5, 1290, (2022). View articlePMID: 36434094

Cross References

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