H
IPR036525

Tubulin/FtsZ, GTPase domain superfamily

InterPro entry
Short nameTubulin/FtsZ_GTPase_sf
Overlapping entries
 

Description

This entry represents a GTPase domain found in all tubulin chains, such as tubulin alpha, beta and gamma chains, plant ARC3 and prokaryotic FtsZ and CetZ proteins
[3, 7]
. These proteins are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ (homologue of eukaryotic tubulin) is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells
[1, 2]
. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea. CetZ co-exists with FtsZ in many archaea. Cetz does not affect cell division, instead, it is involved in cell shape control
[6]
. Arabidopsis chloroplast protein ARC3 (At1g75010) is a Z-ring accessory protein involved in the initiation of plastid division and division site placement
[5, 4]
.

The structure of the GTPase domain has a three layers (α/β/α) with a parallel β-sheet of six strands.

References

1.An essential cell division gene of Drosophila, absent from Saccharomyces, encodes an unusual protein with tubulin-like and myosin-like peptide motifs. Miklos GL, Yamamoto M, Burns RG, Maleszka R. Proc. Natl. Acad. Sci. U.S.A. 94, 5189-94, (1997). View articlePMID: 9144213

2.Crystal structure of the bacterial cell-division protein FtsZ. Lowe J, Amos LA. Nature 391, 203-6, (1998). View articlePMID: 9428770

3.Tubulin and FtsZ form a distinct family of GTPases. Nogales E, Downing KH, Amos LA, Lowe J. Nat. Struct. Biol. 5, 451-8, (1998). View articlePMID: 9628483

4.Effects of arc3, arc5 and arc6 mutations on plastid morphology and stromule formation in green and nongreen tissues of Arabidopsis thaliana. Holzinger A, Kwok EY, Hanson MR. Photochem. Photobiol. 84, 1324-35, (2008). View articlePMID: 18764889

5.ARC3, a chloroplast division factor, is a chimera of prokaryotic FtsZ and part of eukaryotic phosphatidylinositol-4-phosphate 5-kinase. Shimada H, Koizumi M, Kuroki K, Mochizuki M, Fujimoto H, Ohta H, Masuda T, Takamiya K. Plant Cell Physiol. 45, 960-7, (2004). View articlePMID: 15356321

6.CetZ tubulin-like proteins control archaeal cell shape. Duggin IG, Aylett CH, Walsh JC, Michie KA, Wang Q, Turnbull L, Dawson EM, Harry EJ, Whitchurch CB, Amos LA, Lowe J. Nature (2014). PMID: 25533961

7.The role of dynamic instability in microtubule organization. Horio T, Murata T. Front Plant Sci 5, 511, (2014). PMID: 25339962

Cross References

Contributing Member Database Entries
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.