H
IPR036619

NinB superfamily

InterPro entry
Short nameNinB_sf
Overlapping entries
 
Recombinase NinB (IPR008711)

Description

The ninR region of Bacteriophage lambda contains two recombination genes, ninB and ninG (rap), that have roles when the RecF and RecBCD recombination pathways of Escherichia coli, respectively, operate on phage lambda
[2]
. Genetic recombination in phage lambda relies on DNA end processing by Exo to expose 3'-tailed strands for annealing and exchange by beta protein. Phage lambda encodes an additional recombinase, NinB, which participates in the early stages of recombination by supplying a function equivalent to the E. coli RecFOR complex. These host enzymes assist loading of the RecA strand exchange protein onto ssDNA coated with ssDNA-binding protein. NinB has two structural domains with unusual folds, and exists as an intertwined dimer
[1]
.

References

1.Functional similarities between phage lambda Orf and Escherichia coli RecFOR in initiation of genetic exchange. Maxwell KL, Reed P, Zhang RG, Beasley S, Walmsley AR, Curtis FA, Joachimiak A, Edwards AM, Sharples GJ. Proc. Natl. Acad. Sci. U.S.A. 102, 11260-5, (2005). View articlePMID: 16076958

2.Gene products encoded in the ninR region of phage lambda participate in Red-mediated recombination. Tarkowski TA, Mooney D, Thomason LC, Stahl FW. Genes Cells 7, 351-63, (2002). View articlePMID: 11952832

Contributing Member Database Entries
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.