H
IPR036709

Autotransporter beta-domain superfamily

InterPro entry
Short nameAutotransporte_beta_dom_sf
Overlapping entries
 

Description

Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type V pathway was first described for the IgA1 protease
[2]
. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters
[4, 3]
. This superfamily corresponds to the presumed integral membrane β-barrel domain that transports the protein. This domain is found at the C terminus of the proteins it occurs in. The N terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different protease is used and in some cases no cleavage occurs
[1, 4]
.

References

1.The great escape: structure and function of the autotransporter proteins. Henderson IR, Navarro-Garcia F, Nataro JP. Trends Microbiol. 6, 370-8, (1998). View articlePMID: 9778731

2.Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease. Pohlner J, Halter R, Beyreuther K, Meyer TF. Nature 325, 458-62, (1987). View articlePMID: 3027577

3.Crystal structure of a full-length autotransporter. van den Berg B. J. Mol. Biol. 396, 627-33, (2010). View articlePMID: 20060837

4.Structure of the translocator domain of a bacterial autotransporter. Oomen CJ, van Ulsen P, van Gelder P, Feijen M, Tommassen J, Gros P. EMBO J. 23, 1257-66, (2004). View articlePMID: 15014442

Cross References

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