H
IPR036772

SRCR-like domain superfamily

InterPro entry
Short nameSRCR-like_dom_sf
Overlapping entries
 
SRCR domain (IPR001190)

Description

The scavenger receptor cysteine-rich (SRCR) domain is an ancient and highly conserved domain of about 110 residues which is found in diverse secreted and cell-surface proteins, like the type I scavenger receptor, the speract receptor, CD5/Ly-1, CD6, or complement factor I
[3]
. Tandem repeats of SRCR domains are common in the membrane bound proteins. Most SRCR domains have six to eight cysteines that participate in intradomain disulfide bonds. SRCR domains have been subdivided into two groups, A and B, primarily on the differences in the spacing pattern between the cysteine residues
[2, 1]
. Besides type I scavenger receptor, this domain can also be found in the N-terminal of hepsin
[4]
.

The core structure of SRCR has a β-x-α-β-loop-β fold.

References

1.Crystal structure of a scavenger receptor cysteine-rich domain sheds light on an ancient superfamily. Hohenester E, Sasaki T, Timpl R. Nat. Struct. Biol. 6, 228-32, (1999). View articlePMID: 10074941

2.The SRCR superfamily: a family reminiscent of the Ig superfamily. Resnick D, Pearson A, Krieger M. Trends Biochem. Sci. 19, 5-8, (1994). View articlePMID: 8140623

3.An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors. Freeman M, Ashkenas J, Rees DJ, Kingsley DM, Copeland NG, Jenkins NA, Krieger M. Proc. Natl. Acad. Sci. U.S.A. 87, 8810-4, (1990). View articlePMID: 1978939

4.The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain. Somoza JR, Ho JD, Luong C, Ghate M, Sprengeler PA, Mortara K, Shrader WD, Sperandio D, Chan H, McGrath ME, Katz BA. Structure 11, 1123-31, (2003). View articlePMID: 12962630

GO terms

biological process

  • None

molecular function

  • None

cellular component

Cross References

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