H
IPR036788

Translation initiation factor 3 (IF-3), C-terminal domain superfamily

InterPro entry
Short nameT_IF-3_C_sf
Overlapping entries
 

Description

Initiation factor 3 (IF-3) (gene infC) is one of the three factors required for the initiation of protein biosynthesis in bacteria. IF-3 is thought to function as a fidelity factor during the assembly of the ternary initiation complex which consist of the 30S ribosomal subunit, the initiator tRNA and the messenger RNA. IF-3 is a basic protein that binds to the 30S ribosomal subunit
[2]
. The chloroplast initiation factor IF-3(chl) is a protein that enhances the poly(A,U,G)-dependent binding of the initiator tRNA to chloroplast ribosomal 30s subunits in which the central section is evolutionary related to the sequence of bacterial IF-3
[1]
.

The C-terminal domain of IF-3 has a β-α-β-α-β(2) fold arranged into two layers with mixed sheet and strand 4 antiparallel to the rest.

References

1.Isolation and characterization of cDNA clones for chloroplast translational initiation factor-3 from Euglena gracilis. Lin Q, Ma L, Burkhart W, Spremulli LL. J. Biol. Chem. 269, 9436-44, (1994). View articlePMID: 8144528

2.Molecular cloning and sequencing of infC, the gene encoding translation initiation factor IF3, from four enterobacterial species. Liveris D, Schwartz JJ, Geertman R, Schwartz I. FEMS Microbiol. Lett. 112, 211-6, (1993). View articlePMID: 8405963

GO terms

molecular function

  • None

cellular component

  • None
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