H
IPR037030

Retinal cGMP phosphodiesterase, gamma subunit superfamily

InterPro entry
Short namePDE6_gamma_sf
Overlapping entries
 

Description

Retinal rod and cone cGMP phosphodiesterases function as the effector enzymes in the vertebrate visual transduction cascade. This entry represents the inhibitory gamma subunit
[2]
, which is also expressed outside retinal tissues and has been shown to interact with the G-protein-coupled receptor kinase 2 signalling system to regulate the epidermal growth factor- and thrombin-dependent stimulation of p42/p44 mitogen-activated protein kinase in human embryonic kidney 293 cells
[1]
.

The gamma subunit is intrinsically disordered and its interaction with the alpha subunit involves the selection of preconfigured transient conformations
[3]
.

References

1.The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cells. Wan KF, Sambi BS, Frame M, Tate R, Pyne NJ. J. Biol. Chem. 276, 37802-8, (2001). View articlePMID: 11502744

2.Direct interaction of the inhibitory gamma-subunit of Rod cGMP phosphodiesterase (PDE6) with the PDE6 GAFa domains. Muradov KG, Granovsky AE, Schey KL, Artemyev NO. Biochemistry 41, 3884-90, (2002). View articlePMID: 11900530

3.Intrinsically disordered gamma-subunit of cGMP phosphodiesterase encodes functionally relevant transient secondary and tertiary structure. Song J, Guo LW, Muradov H, Artemyev NO, Ruoho AE, Markley JL. Proc. Natl. Acad. Sci. U.S.A. 105, 1505-10, (2008). View articlePMID: 18230733

GO terms

Cross References

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