IPR037033
DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily
InterPro entry
Short name | DNA-dir_RNAP_su2_hyb_sf |
Overlapping entries |
Description
RNA polymerases (
2.7.7.6) catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial and chloroplast polymerases). This entry represents the hybrid-binding and the wall domain superfamily
[1]. The hybrid-binding domain binds the nascent RNA strand/template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion
[1]. It is also involved in binding to Rpb1 and Rpb3
[1]. Many of the bacterial members contain large insertions within this domain, which are known as dispensable region 2 (DRII).
References
1.Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution. Cramer P, Bushnell DA, Kornberg RD. Science 292, 1863-76, (2001). View articlePMID: 11313498
GO terms
biological process
cellular component
- None
Cross References
Contributing Member Database Entry
- CATH-Gene3D:G3DSA:2.40.270.10