SOCS6, SOCS box domain
Short name | SOCS6_SOCS |
Overlapping homologous superfamilies | |
domain relationships |
Description
References
1.Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase. Bullock AN, Debreczeni JE, Edwards AM, Sundstrom M, Knapp S. Proc. Natl. Acad. Sci. U.S.A. 103, 7637-42, (2006). View articlePMID: 16675548
2.Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase. Zadjali F, Pike AC, Vesterlund M, Sun J, Wu C, Li SS, Ronnstrand L, Knapp S, Bullock AN, Flores-Morales A. J. Biol. Chem. 286, 480-90, (2011). View articlePMID: 21030588
3.Suppressor of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated tyrosines 591 and 919 of Flt3. Kazi JU, Sun J, Phung B, Zadjali F, Flores-Morales A, Ronnstrand L. J. Biol. Chem. 287, 36509-17, (2012). View articlePMID: 22952242
4.The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Kamura T, Sato S, Haque D, Liu L, Kaelin WG Jr, Conaway RC, Conaway JW. Genes Dev. 12, 3872-81, (1998). View articlePMID: 9869640
GO terms
biological process
molecular function
- None
cellular component
- None
Contributing Member Database Entry
- CDD:cd03740