D
IPR037454

PACSIN1, F-BAR

InterPro entry
Short namePACSIN1_F-BAR
Overlapping
homologous
superfamilies
 
domain relationships

Description

PACSIN1 (protein kinase C and casein kinase substrate in neurons protein 1, also known as SYNDAPIN1) belongs to the PACSIN family that contains a N-terminal F-BAR (FCH-BAR) domain and a C-terminal SH3 domain
[4]
. There are three tissue-specific isoforms of PACSIN1 found in mammals: PACSIN11 is enriched in neurons, PACSIN12 is ubiquitously expressed, and PACSIN13 is found mainly in muscle
[4]
. They are cytoplasmic phosphoproteins that play a role in vesicle formation and transport
[5]
.

PACSIN1 is upregulated upon differentiation into neuronal cells
[3]
. The SH3 domain of PACSIN1 mediates activation of neural WASP (N-WASP), which is required to regulate actin polymerisation and is essential for proper neuromorphogenesis and cellular motility
[2]
. Two phosphorylation sites within the F-BAR domain of PACSIN1 are used for membrane tubulation regulation
[6]
.

This entry represents the F-BAR domain of PACSIN1. F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization
[1]
.

References

1.Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin. Wang Q, Navarro MV, Peng G, Molinelli E, Shih LG, Judson BL, Rajashankar KR, Sondermann H. Proc. Natl. Acad. Sci. U.S.A. (2009). PMID: 19549836

2.F-BAR proteins of the syndapin family shape the plasma membrane and are crucial for neuromorphogenesis. Dharmalingam E, Haeckel A, Pinyol R, Schwintzer L, Koch D, Kessels MM, Qualmann B. J. Neurosci. 29, 13315-27, (2009). View articlePMID: 19846719

3.PACSIN, a brain protein that is upregulated upon differentiation into neuronal cells. Plomann M, Lange R, Vopper G, Cremer H, Heinlein UA, Scheff S, Baldwin SA, Leitges M, Cramer M, Paulsson M, Barthels D. Eur. J. Biochem. 256, 201-11, (1998). View articlePMID: 9746365

4.Versatile membrane deformation potential of activated pacsin. Goh SL, Wang Q, Byrnes LJ, Sondermann H. PLoS ONE 7, e51628, (2012). View articlePMID: 23236520

5.PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family. Sumoy L, Pluvinet R, Andreu N, Estivill X, Escarceller M. Gene 262, 199-205, (2001). View articlePMID: 11179684

6.Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation. Quan A, Xue J, Wielens J, Smillie KJ, Anggono V, Parker MW, Cousin MA, Graham ME, Robinson PJ. Proc. Natl. Acad. Sci. U.S.A. 109, 3760-5, (2012). View articlePMID: 22355135

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