D
IPR037627

SASH1, SAM domain repeat 1

InterPro entry
Short nameSASH1_SAM_repeat1
Overlapping
homologous
superfamilies
 
domain relationships

Description

This entry represents the SAM (sterile alpha motif) domain repeat 1 of SASH1, which is a predicted protein-protein interaction domain. SASH1 contains an SH3 domain and two SAM domains, and is a member of the SH3/SAM adapter molecules family. SASH1 has been identified as a tumour suppressor and critical protein in signal transduction
[1, 2]
.

References

1.SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer. Zeller C, Hinzmann B, Seitz S, Prokoph H, Burkhard-Goettges E, Fischer J, Jandrig B, Schwarz LE, Rosenthal A, Scherneck S. Oncogene 22, 2972-83, (2003). View articlePMID: 12771949

2.Correlation of SASH1 expression and ultrasonographic features in breast cancer. Gong X, Wu J, Wu J, Liu J, Gu H, Shen H. Onco Targets Ther 10, 271-276, (2017). View articlePMID: 28138250

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