IPR037875
Ribosome biogenesis protein Bms1, N-terminal
InterPro entry
Short name | Bms1_N |
Overlapping homologous superfamilies |
Description
Bms1 is an essential, evolutionarily conserved, nucleolar protein. Its depletion interferes with processing of the 35S pre-rRNA at sites A0, A1, and A2, and the formation of 40S subunits. Bms1, the putative endonuclease Rc11, and the essential U3 small nucleolar RNA form a stable subcomplex that is believed to control an early step in the formation of the 40S subunit
[2]. The N terminus of Bms1 contains a guanine nucleotide-binding (G) domain that functions intramolecularly. It is believed that Rc11 activates Bms1 by acting as a guanine-nucleotide exchange factor (GEF) to promote GDP/GTP exchange, and that activated (GTP-bound) Bms1 delivers Rc11 to the preribosomes
[1].
This entry represents the N-terminal domain of Bms1.
References
1.Bms1p, a G-domain-containing protein, associates with Rcl1p and is required for 18S rRNA biogenesis in yeast. Wegierski T, Billy E, Nasr F, Filipowicz W. RNA 7, 1254-67, (2001). View articlePMID: 11565748
2.GTP-dependent formation of a ribonucleoprotein subcomplex required for ribosome biogenesis. Karbstein K, Doudna JA. J. Mol. Biol. 356, 432-43, (2006). View articlePMID: 16376378
GO terms
Contributing Member Database Entry
- CDD:cd01882