D
IPR037974

BICC1, SAM domain

InterPro entry
Short nameBICC1_SAM_dom
Overlapping
homologous
superfamilies
 
domain relationships

Description

Bicaudal-C (BICC, BICC1 in vertebrates) is an RNA-binding protein with translational repression function
[2]
. It is involved in the regulation of embryonic differentiation and plays a role in the regulation of Dvl (Dishevelled) signaling, particularly in the correct cilia orientation and nodal flow generation
[5]
. In Drosophila, disruption of BICC can disturb the normal migration direction of the anterior follicle cell of oocytes
[1]
. In mammals, mutations in this gene are associated with polycystic kidney disease and it was suggested that the BICC1 protein can indirectly interact with ANKS6 protein (ANKS6 is also associated with polycystic kidney disease) through some protein and RNA intermediates
[4]
.

BICC1 contains N-terminal K homology RNA-binding vigilin-like repeats and a C-terminal SAM domain. This entry represents the SAM (sterile alpha motif) domain, which is a protein-protein interaction domain
[3]
.

References

1.Premature translation of oskar in oocytes lacking the RNA-binding protein bicaudal-C. Saffman EE, Styhler S, Rother K, Li W, Richard S, Lasko P. Mol. Cell. Biol. 18, 4855-62, (1998). View articlePMID: 9671494

2.A gradient of maternal Bicaudal-C controls vertebrate embryogenesis via translational repression of mRNAs encoding cell fate regulators. Park S, Blaser S, Marchal MA, Houston DW, Sheets MD. Development 143, 864-71, (2016). View articlePMID: 26811381

3.The many faces of SAM. Qiao F, Bowie JU. Sci. STKE 2005, re7, (2005). View articlePMID: 15928333

4.The polycystic kidney disease-related proteins Bicc1 and SamCystin interact. Stagner EE, Bouvrette DJ, Cheng J, Bryda EC. Biochem. Biophys. Res. Commun. 383, 16-21, (2009). View articlePMID: 19324013

5.Bicaudal C, a novel regulator of Dvl signaling abutting RNA-processing bodies, controls cilia orientation and leftward flow. Maisonneuve C, Guilleret I, Vick P, Weber T, Andre P, Beyer T, Blum M, Constam DB. Development 136, 3019-30, (2009). View articlePMID: 19666828

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