H
IPR038107

3-deoxy-D-manno-octulosonic-acid transferase, N-terminal domain superfamily

InterPro entry
Short nameGlycos_transf_N_sf
Overlapping entries
 

Description

3-deoxy-D-manno-octulosonic-acid transferase (WaaA, KdtA) is involved in lipopolysaccharide biosynthesis. It catalyses the transfer of two 3-deoxy-D-manno-octulosonate (Kdo) residues from CMP-Kdo to lipid IV(A), the precursor of lipid A
[2]
. WaaA consists of two Rossmann-like domains. This superfamily represents the N-terminal domain, which is the acceptor-substrate binding domain. Structurally, it consists of 7 α-helices and 5 β-strands
[1]
.

References

1.Structural and mechanistic analysis of the membrane-embedded glycosyltransferase WaaA required for lipopolysaccharide synthesis. Schmidt H, Hansen G, Singh S, Hanuszkiewicz A, Lindner B, Fukase K, Woodard RW, Holst O, Hilgenfeld R, Mamat U, Mesters JR. Proc. Natl. Acad. Sci. U.S.A. 109, 6253-8, (2012). PMID: 22474366

2.Comparative analyses of secondary gene products of 3-deoxy-D-manno-oct-2-ulosonic acid transferases from Chlamydiaceae in Escherichia coli K-12. Brabetz W, Lindner B, Brade H. Eur. J. Biochem. 267, 5458-65, (2000). View articlePMID: 10951204

Cross References

Contributing Member Database Entry
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.