IPR038107
3-deoxy-D-manno-octulosonic-acid transferase, N-terminal domain superfamily
InterPro entry
Short name | Glycos_transf_N_sf |
Overlapping entries |
Description
3-deoxy-D-manno-octulosonic-acid transferase (WaaA, KdtA) is involved in lipopolysaccharide biosynthesis. It catalyses the transfer of two 3-deoxy-D-manno-octulosonate (Kdo) residues from CMP-Kdo to lipid IV(A), the precursor of lipid A
[2]. WaaA consists of two Rossmann-like domains. This superfamily represents the N-terminal domain, which is the acceptor-substrate binding domain. Structurally, it consists of 7 α-helices and 5 β-strands
[1].
References
1.Structural and mechanistic analysis of the membrane-embedded glycosyltransferase WaaA required for lipopolysaccharide synthesis. Schmidt H, Hansen G, Singh S, Hanuszkiewicz A, Lindner B, Fukase K, Woodard RW, Holst O, Hilgenfeld R, Mamat U, Mesters JR. Proc. Natl. Acad. Sci. U.S.A. 109, 6253-8, (2012). PMID: 22474366
2.Comparative analyses of secondary gene products of 3-deoxy-D-manno-oct-2-ulosonic acid transferases from Chlamydiaceae in Escherichia coli K-12. Brabetz W, Lindner B, Brade H. Eur. J. Biochem. 267, 5458-65, (2000). View articlePMID: 10951204
Cross References
Contributing Member Database Entry
- CATH-Gene3D:G3DSA:3.40.50.11720