H
IPR038177

Inverse autotransporter, beta-domain superfamily

InterPro entry
Short nameIAT_beta_sf
Overlapping entries
 

Description

This domain is found in a group of β-barrel porin-like outer membrane proteins from enteropathogenic Gram-negative bacteria. Intimins and invasins are virulence factors produced by pathogenic Gram-negative bacteria. They carry C-terminal extracellular passenger domains that are involved in adhesion to host cells and N-terminal beta domains that are embedded in the outer membrane. This entry represents the β-barrel porin-like domain in the outer membrane that can be found in intimins, invasins and other inverse autotransporters
[3, 2]
.

Intimin is believed to mediate adherence and it is necessary for the production of attaching and effacing lesions on tissue culture cells
[5]
. Invasin is a protein that allows enteric bacteria to penetrate cultured mammalian cells
[4]
. The entry of invasin in the cell is mediated by binding several beta-1 chain integrins
[1]
.

References

1.Crystal structure of invasin: a bacterial integrin-binding protein. Hamburger ZA, Brown MS, Isberg RR, Bjorkman PJ. Science 286, 291-5, (1999). View articlePMID: 10514372

2.The inverse autotransporter family: intimin, invasin and related proteins. Leo JC, Oberhettinger P, Schutz M, Linke D. Int. J. Med. Microbiol. 305, 276-82, (2015). View articlePMID: 25596886

3.Crystal Structures of the Outer Membrane Domain of Intimin and Invasin from Enterohemorrhagic E. coli and Enteropathogenic Y. pseudotuberculosis. Fairman JW, Dautin N, Wojtowicz D, Liu W, Noinaj N, Barnard TJ, Udho E, Przytycka TM, Cherezov V, Buchanan SK. Structure (2012). PMID: 22658748

4.Identification of invasin: a protein that allows enteric bacteria to penetrate cultured mammalian cells. Isberg RR, Voorhis DL, Falkow S. Cell 50, 769-78, (1987). View articlePMID: 3304658

5.A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells. Jerse AE, Yu J, Tall BD, Kaper JB. Proc. Natl. Acad. Sci. U.S.A. 87, 7839-43, (1990). View articlePMID: 2172966

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