H
IPR038545

DBF-type zinc finger superfamily

InterPro entry
Short nameZnf_DBF_sf
Overlapping entries
 

Description

In eukaryotes, initiation of DNA replication requires the assembly of pre-replication complexes (pre-RCs) on chromatin during the G1 phase. In the S phase, pre-RCs are activated by two protein kinases, Cdk2 and Cdc7, which results in the loading of replication factors and the unwinding of replication origins by the MCM helicase complex
[4]
. Cdc7 is a serine/threonine kinase that is conserved from yeast to human. It is regulated by its association with a regulatory subunit, the Dbf4 protein. This complex is often referred to as DDK (Dbf4-dependent kinase)
[3]
.

DBF4 contains an N-terminal BRCT domain and a C-terminal conserved region that could potentially coordinate one zinc atom, the DBF4-type zinc finger. This entry represents the zinc finger, which is important for the interaction with Cdc7
[2, 1]
.

References

1.Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo. Dowell SJ, Romanowski P, Diffley JF. Science 265, 1243-6, (1994). View articlePMID: 8066465

2.A novel role for Cdc5p in DNA replication. Hardy CF, Pautz A. Mol. Cell. Biol. 16, 6775-82, (1996). View articlePMID: 8943332

3.Cdc7 kinases (DDKs) and checkpoint responses: lessons from two yeasts. Duncker BP, Brown GW. Mutat. Res. 532, 21-7, (2003). View articlePMID: 14643426

4.Viewpoint: putting the cell cycle in order. Nasmyth K. Science 274, 1643-5, (1996). View articlePMID: 8984634

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