IPR038545
DBF-type zinc finger superfamily
InterPro entry
Short name | Znf_DBF_sf |
Overlapping entries |
Description
In eukaryotes, initiation of DNA replication requires the assembly of pre-replication complexes (pre-RCs) on chromatin during the G1 phase. In the S phase, pre-RCs are activated by two protein kinases, Cdk2 and Cdc7, which results in the loading of replication factors and the unwinding of replication origins by the MCM helicase complex
[4]. Cdc7 is a serine/threonine kinase that is conserved from yeast to human. It is regulated by its association with a regulatory subunit, the Dbf4 protein. This complex is often referred to as DDK (Dbf4-dependent kinase)
[3].
References
1.Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo. Dowell SJ, Romanowski P, Diffley JF. Science 265, 1243-6, (1994). View articlePMID: 8066465
2.A novel role for Cdc5p in DNA replication. Hardy CF, Pautz A. Mol. Cell. Biol. 16, 6775-82, (1996). View articlePMID: 8943332
3.Cdc7 kinases (DDKs) and checkpoint responses: lessons from two yeasts. Duncker BP, Brown GW. Mutat. Res. 532, 21-7, (2003). View articlePMID: 14643426
4.Viewpoint: putting the cell cycle in order. Nasmyth K. Science 274, 1643-5, (1996). View articlePMID: 8984634
Contributing Member Database Entry
- CATH-Gene3D:G3DSA:6.10.250.3410