H
IPR038586

Tctex-1-like superfamily

InterPro entry
Short nameTctex-1-like_sf
Overlapping entries
 

Description

Tctex-1 is a dynein light chain. Dynein translocates rhodopsin-bearing vesicles along microtubules and it has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin for retrograde or apical transport
[4]
. An efficient vectorial transport system must be required to deliver large numbers of newly synthesised rhodopsin molecules (~107molecules per day per photoreceptor) to the base of the outer segment of the photoreceptor, Tctex-1 may well play a role in this process. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit the interaction between Tctex-1 and rhodopsin, which may be the molecular basis of retinitis pigmentosa
[1]
.

In the mouse, the chromosomal location and pattern of expression of Tctex-1 make it a candidate for involvement in male sterility
[3]
.

This entry also includes Topoisomerase I damage affected protein 2 (TDA2) whose crystal structure revealed that it belongs to the dynein light chain family. It is part of the endocytic machinery and required for normal internalisation of native cargo in yeast
[2]
.

References

1.Rhodopsin's carboxy-terminal cytoplasmic tail acts as a membrane receptor for cytoplasmic dynein by binding to the dynein light chain Tctex-1. Tai AW, Chuang JZ, Bode C, Wolfrum U, Sung CH. Cell 97, 877-87, (1999). View articlePMID: 10399916

2.Novel function of a dynein light chain in actin assembly during clathrin-mediated endocytosis. Farrell KB, McDonald S, Lamb AK, Worcester C, Peersen OB, Di Pietro SM. J Cell Biol 216, 2565-2580, (2017). PMID: 28706108

3.tctex-1: a candidate gene family for a mouse t complex sterility locus. Lader E, Ha HS, O'Neill M, Artzt K, Bennett D. Cell 58, 969-79, (1989). View articlePMID: 2570638

4.Crystal structure of dynein light chain TcTex-1. Williams JC, Xie H, Hendrickson WA. J. Biol. Chem. 280, 21981-6, (2005). View articlePMID: 15701632

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