H
IPR038693

Phenylacetyl-CoA epoxidase, subunit B

InterPro entry
Short namePaaB_sf
Overlapping entries
 

Description

This entry represents the 1,2-phenylacetyl-CoA epoxidase, subunit B (also known as PaaB) and related bacterial proteins.

Phenylacetyl-CoA monooxygenase (epoxidase) is a multicomponent enzyme, PaaABC(D)E, responsible for the hydroxylation of phenylacetate-CoA (PA-CoA) as the second catabolic step in phenylacetic acid (PA) degradation
[5, 4, 2]
. Not only transforms phenylacetyl-CoA into its ring-1,2-epoxide, but also mediates the NADPH-dependent removal of the epoxide oxygen, regenerating phenylacetyl-CoA with formation of water
[3]
.

The PaaB subunit probably acts as an effector protein
[1]
.

References

1.Bacterial phenylalanine and phenylacetate catabolic pathway revealed. Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G. Proc. Natl. Acad. Sci. U.S.A. 107, 14390-5, (2010). View articlePMID: 20660314

2.Structural and functional studies of the Escherichia coli phenylacetyl-CoA monooxygenase complex. Grishin AM, Ajamian E, Tao L, Zhang L, Menard R, Cygler M. J. Biol. Chem. 286, 10735-43, (2011). View articlePMID: 21247899

3.An oxygenase that forms and deoxygenates toxic epoxide. Teufel R, Friedrich T, Fuchs G. Nature 483, 359-62, (2012). View articlePMID: 22398448

4.Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway. Ferrandez A, Minambres B, Garcia B, Olivera ER, Luengo JM, Garcia JL, Diaz E. J. Biol. Chem. 273, 25974-86, (1998). View articlePMID: 9748275

5.Molecular characterization of the phenylacetic acid catabolic pathway in Pseudomonas putida U: the phenylacetyl-CoA catabolon. Olivera ER, Minambres B, Garcia B, Muniz C, Moreno MA, Ferrandez A, Diaz E, Garcia JL, Luengo JM. Proc. Natl. Acad. Sci. U.S.A. 95, 6419-24, (1998). View articlePMID: 9600981

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