D
IPR038729

Rad50/SbcC-type AAA domain

InterPro entry
Short nameRad50/SbcC_AAA
Overlapping
homologous
superfamilies
 

Description

This entry represents the AAA domain found in some DNA repair proteins, such as Rad50, SbcC, RecF, RecN and structural maintenance of chromosomes proteins 5 and 6 (Smc5-Smc6)
[2, 1, 3]
.

AAA ATPases belong to the AAA+ superfamily of ringshaped P-loop NTPases, which exert their activity through the energy-dependent unfolding of macromolecules
[4]
.

References

1.Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 during Replication Stress. Oravcova M, Gadaleta MC, Nie M, Reubens MC, Limbo O, Russell P, Boddy MN. Mol Cell Biol 39, e00271-18, (2019). PMID: 30348841

2.RAD50, an SMC family member with multiple roles in DNA break repair: how does ATP affect function? Kinoshita E, van der Linden E, Sanchez H, Wyman C. Chromosome Res 17, 277-88, (2009). PMID: 19308707

3.The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity. Ghosal G, Muniyappa K. J. Mol. Biol. 372, 864-82, (2007). View articlePMID: 17698079

4.Phylogenetic analysis of AAA proteins. Frickey T, Lupas AN. J. Struct. Biol. 146, 2-10, (2004). View articlePMID: 15037233

GO terms

cellular component

  • None

Cross References

Contributing Member Database Entry
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