F
IPR039398

Deltex family

InterPro entry
Short nameDeltex_fam
Overlapping
homologous
superfamilies
 

Description

The deltex family of proteins is involved in the regulation of Notch signaling, and therefore may play roles in cell-to-cell communications that regulate mechanisms determining cell fate
[4]
. They have a central RING-type zinc finger domain and contain a C-terminal domain that is also found in other domain architectures. Deltex-1 (DTX1) contains a RING finger and two WWE domains, indicating that it may be an E3 ubiquitin ligase
[3]
. Human deltex 3-like, which contains an additional N-terminal domain (presumably with ubiquitin ligase activity) is also described as E3 ubiquitin-protein ligase DTX3L, B-lymphoma- and BAL-associated protein (BBAP), or rhysin-2. DTX3L mediates monoubiquitination of K91 of histone H4 in response to DNA damage
[1, 2]
.

References

1.Fold of the conserved DTC domain in Deltex proteins. Obiero J, Walker JR, Dhe-Paganon S. Proteins 80, 1495-9, (2012). View articlePMID: 22411408

2.The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA. J. Biol. Chem. 278, 21930-7, (2003). View articlePMID: 12670957

3.Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness. Zhang P, Yang Y, Nolo R, Zweidler-McKay PA, Hughes DP. Oncogene 29, 2916-26, (2010). View articlePMID: 20208568

4.Human deltex is a conserved regulator of Notch signalling. Matsuno K, Eastman D, Mitsiades T, Quinn AM, Carcanciu ML, Ordentlich P, Kadesch T, Artavanis-Tsakonas S. Nat. Genet. 19, 74-8, (1998). View articlePMID: 9590294

GO terms

molecular function

  • None

cellular component

  • None

Cross References

Contributing Member Database Entry
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