F
IPR039428

NADH-ubiquinone oxidoreductase chain 4L/Mnh complex subunit C1-like

InterPro entry
Short nameNUOK/Mnh_C1-like
family relationships

Description

This entry includes NADH:ubiquinone oxidoreductase, chain 4L and bacterial Mnh complex subunit C. They share significant protein sequence similarity
[3]
.

ADH:ubiquinone oxidoreductase (complex I) (
1.6.5.3
) is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol)
[5]
. In eukaryotes, NADH:ubiquinone oxidoreductase, chain 4L is usually found in either mitochondria or chloroplasts as part of the respiratory-chain NADH dehydrogenase (also known as complex I or NADH-ubiquinone oxidoreductase), an oligomeric enzymatic complex
[4]
. However, it is also found in bacteria
[2]
and archaea
[1]
where it is annotated as NuoK subunit.

Mnh subunit C1 is a cation antiporter, involved in K(+) and Na(+) excretion
[3]
.

References

1.The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound multisubunit hydrogenases. Friedrich T, Scheide D. FEBS Lett. 479, 1-5, (2000). View articlePMID: 10940377

2.Production of reactive oxygen species by complex I (NADH:ubiquinone oxidoreductase) from Escherichia coli and comparison to the enzyme from mitochondria. Esterhazy D, King MS, Yakovlev G, Hirst J. Biochemistry 47, 3964-71, (2008). View articlePMID: 18307315

3.Catalytic properties of Staphylococcus aureus and Bacillus members of the secondary cation/proton antiporter-3 (Mrp) family are revealed by an optimized assay in an Escherichia coli host. Swartz TH, Ito M, Ohira T, Natsui S, Hicks DB, Krulwich TA. J. Bacteriol. 189, 3081-90, (2007). View articlePMID: 17293423

4.Tracing the evolution of a large protein complex in the eukaryotes, NADH:ubiquinone oxidoreductase (Complex I). Gabaldon T, Rainey D, Huynen MA. J. Mol. Biol. 348, 857-70, (2005). View articlePMID: 15843018

5.The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains. Walker JE. Q. Rev. Biophys. 25, 253-324, (1992). PMID: 1470679

Cross References

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