F
IPR039682

Exocyst complex component Sec8/EXOC4

InterPro entry
Short nameSec8/EXOC4

Description

This entry includes Sec8 from fungi and EXOC4 from animals. Sec8 is a component of the exocyst complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane
[1]
. In fission yeasts, the exocyst complex is also required for polarized cell growth and division septum assembly
[3]
. EXOC4 has been shown to regulate N-cadherin expression by controlling Smad3 and Smad4 expression through CREB binding protein, thereby mediating the epithelial-mesenchymal transition and early embryonic development
[2]
.

References

1.The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae. TerBush DR, Maurice T, Roth D, Novick P. EMBO J. 15, 6483-94, (1996). View articlePMID: 8978675

2.Sec8 modulates TGF-β induced EMT by controlling N-cadherin via regulation of Smad3/4. Tanaka T, Goto K, Iino M. Cell. Signal. 29, 115-126, (2017). View articlePMID: 27769780

3.Role of septins and the exocyst complex in the function of hydrolytic enzymes responsible for fission yeast cell separation. Martin-Cuadrado AB, Morrell JL, Konomi M, An H, Petit C, Osumi M, Balasubramanian M, Gould KL, Del Rey F, de Aldana CR. Mol. Biol. Cell 16, 4867-81, (2005). View articlePMID: 16079182

GO terms

molecular function

  • None

cellular component

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