IPR039682
Exocyst complex component Sec8/EXOC4
InterPro entry
Short name | Sec8/EXOC4 |
Description
This entry includes Sec8 from fungi and EXOC4 from animals. Sec8 is a component of the exocyst complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane
[1]. In fission yeasts, the exocyst complex is also required for polarized cell growth and division septum assembly
[3]. EXOC4 has been shown to regulate N-cadherin expression by controlling Smad3 and Smad4 expression through CREB binding protein, thereby mediating the epithelial-mesenchymal transition and early embryonic development
[2].
References
1.The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae. TerBush DR, Maurice T, Roth D, Novick P. EMBO J. 15, 6483-94, (1996). View articlePMID: 8978675
2.Sec8 modulates TGF-β induced EMT by controlling N-cadherin via regulation of Smad3/4. Tanaka T, Goto K, Iino M. Cell. Signal. 29, 115-126, (2017). View articlePMID: 27769780
3.Role of septins and the exocyst complex in the function of hydrolytic enzymes responsible for fission yeast cell separation. Martin-Cuadrado AB, Morrell JL, Konomi M, An H, Petit C, Osumi M, Balasubramanian M, Gould KL, Del Rey F, de Aldana CR. Mol. Biol. Cell 16, 4867-81, (2005). View articlePMID: 16079182
GO terms
biological process
molecular function
- None
cellular component
Contributing Member Database Entry
- PANTHER:PTHR14146