F
IPR039693

Rtr1/RPAP2

InterPro entry
Short nameRtr1/RPAP2
Overlapping
homologous
superfamilies
 

Description

This entry includes Rtr1 from budding yeasts and its homologues, including RPAP2 from humans. Homologues are known from animals, plants and fungi. Rtr1 and Rtr2 are paralogues. Rtr1 is a RNA polymerase II (RNAPII)-binding protein. It is responsible for the transition of PolII into the elongation and termination phases of transcription by removing RNAPII CTD serine 5 phosphorylation (Ser5-P) at a selection of target genes
[3, 1]
.

Human RPAP2 is a CTD phosphatase that interacts directly with the RNA polymerase II subunit Rpb6 and participates in pre-mRNA 3'-end formation
[2]
.

References

1.Phosphatase Rtr1 Regulates Global Levels of Serine 5 RNA Polymerase II C-Terminal Domain Phosphorylation and Cotranscriptional Histone Methylation. Hunter GO, Fox MJ, Smith-Kinnaman WR, Gogol M, Fleharty B, Mosley AL. Mol. Cell. Biol. 36, 2236-45, (2016). View articlePMID: 27247267

2.Human RNA polymerase II-associated protein 2 (RPAP2) interacts directly with the RNA polymerase II subunit Rpb6 and participates in pre-mRNA 3'-end formation. Wani S, Hirose Y, Ohkuma Y. Drug Discov Ther 8, 255-61, (2014). View articlePMID: 25639305

3.Rtr1 is a CTD phosphatase that regulates RNA polymerase II during the transition from serine 5 to serine 2 phosphorylation. Mosley AL, Pattenden SG, Carey M, Venkatesh S, Gilmore JM, Florens L, Workman JL, Washburn MP. Mol. Cell 34, 168-78, (2009). View articlePMID: 19394294

GO terms

Cross References

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