IPR039758
N-acetyl-D-glucosamine kinase NAGK-like
InterPro entry
Short name | NAGK-like |
Overlapping homologous superfamilies |
Description
This entry includes N-acetyl-D-glucosamine kinases (NAGKs) from prokaryotes and eukaryotes. NAGK converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate
[1]. It has been shown to play an enzyme activity-independent role in human neurons
[2, 3].
References
1.Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid. Bergfeld AK, Pearce OM, Diaz SL, Pham T, Varki A. J. Biol. Chem. 287, 28865-81, (2012). View articlePMID: 22692205
2.N-Acetyl-D-Glucosamine Kinase Promotes the Axonal Growth of Developing Neurons. Islam MA, Sharif SR, Lee H, Moon IS. Mol. Cells 38, 876-85, (2015). View articlePMID: 26467288
3.N-Acetyl-D-Glucosamine Kinase Interacts with Dynein-Lis1-NudE1 Complex and Regulates Cell Division. Sharif SR, Islam A, Moon IS. Mol. Cells 39, 669-79, (2016). View articlePMID: 27646688
GO terms
biological process
- None
molecular function
cellular component
- None
Cross References
Contributing Member Database Entry
- PANTHER:PTHR12862
Representative structure
2ch5: Crystal structure of human N-acetylglucosamine kinase in complex with N-acetylglucosamine