F
IPR039758

N-acetyl-D-glucosamine kinase NAGK-like

InterPro entry
Short nameNAGK-like
Overlapping
homologous
superfamilies
 

Description

This entry includes N-acetyl-D-glucosamine kinases (NAGKs) from prokaryotes and eukaryotes. NAGK converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate
[1]
. It has been shown to play an enzyme activity-independent role in human neurons
[2, 3]
.

References

1.Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid. Bergfeld AK, Pearce OM, Diaz SL, Pham T, Varki A. J. Biol. Chem. 287, 28865-81, (2012). View articlePMID: 22692205

2.N-Acetyl-D-Glucosamine Kinase Promotes the Axonal Growth of Developing Neurons. Islam MA, Sharif SR, Lee H, Moon IS. Mol. Cells 38, 876-85, (2015). View articlePMID: 26467288

3.N-Acetyl-D-Glucosamine Kinase Interacts with Dynein-Lis1-NudE1 Complex and Regulates Cell Division. Sharif SR, Islam A, Moon IS. Mol. Cells 39, 669-79, (2016). View articlePMID: 27646688

GO terms

biological process

  • None

cellular component

  • None

Cross References

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