F
IPR039767

RalA-binding protein 1

InterPro entry
Short nameRALBP1

Description

RALBP1, also known as RLIP76, is a Ral-binding GTPase activating protein implicated in a number of cell processes, including receptor-mediated endocytosis, cell migration, mitochondrial division and metabolite transport
[3]
. It transports glutathione-conjugates of electrophilic compounds and may contribute to the multidrug resistance
[1]
. It has been shown to mediate ATP-dependent transport of glutathione-conjugates and doxorubicin in human erythrocytes
[2]
.

References

1.RLIP76: a versatile transporter and an emerging target for cancer therapy. Vatsyayan R, Lelsani PC, Awasthi S, Singhal SS. Biochem. Pharmacol. 79, 1699-705, (2010). View articlePMID: 20097178

2.RLIP76 is the major ATP-dependent transporter of glutathione-conjugates and doxorubicin in human erythrocytes. Sharma R, Singhal SS, Cheng J, Yang Y, Sharma A, Zimniak P, Awasthi S, Awasthi YC. Arch. Biochem. Biophys. 391, 171-9, (2001). View articlePMID: 11437348

3.Structure and function of RLIP76 (RalBP1): an intersection point between Ras and Rho signalling. Mott HR, Owen D. Biochem. Soc. Trans. 42, 52-8, (2014). View articlePMID: 24450627

GO terms

Cross References

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