F
IPR039791

Chorion-specific transcription factor GCM

InterPro entry
Short nameGCM
Overlapping
homologous
superfamilies
 
GCM, small domain (IPR043021)

Description

GCM transcription factors are a family of proteins which contain a GCM motif. They bind specific sequences on gene promoters and activate their transcription. Human GCM1 is involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes
[1, 2]
. Fruit fly GCM determines the choice between glial and neuronal fates
[3]
.

References

1.A GCM motif protein is involved in placenta-specific expression of human aromatase gene. Yamada K, Ogawa H, Honda S, Harada N, Okazaki T. J. Biol. Chem. 274, 32279-86, (1999). View articlePMID: 10542267

2.Glial cell missing 1 regulates placental growth factor (PGF) gene transcription in human trophoblast. Chang M, Mukherjea D, Gobble RM, Groesch KA, Torry RJ, Torry DS. Biol. Reprod. 78, 841-51, (2008). View articlePMID: 18160678

3.glial cells missing: a genetic switch that controls glial versus neuronal fate. Jones BW, Fetter RD, Tear G, Goodman CS. Cell 82, 1013-23, (1995). View articlePMID: 7553843

GO terms

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