F
IPR040040

Autophagy-related protein 11

InterPro entry
Short nameATG11

Description

Autophagy-related protein 11 (ATG11; also known as cytoplasm to vacuole targeting protein 9) is required for transport of proteins from the cytosol to the vacuole
[1, 2]
, including whole mitochondria for autophagic digestion (mitophagy) in the autophagosome during starvation
[3]
. It also acts as the scaffold that recruit ATG proteins to the pre-autophagosome
[4]
. The orthologue in mammals is known as RB1-inducible coiled-coil protein 1 (RB1CC1)
[5]
; the orthologue in Schizosaccharomyces pombe is Taz1-interacting factor 1 (taf1)
[6]
.

References

1.Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway. Shintani T, Huang WP, Stromhaug PE, Klionsky DJ. Dev. Cell 3, 825-37, (2002). View articlePMID: 12479808

2.Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway. Yorimitsu T, Klionsky DJ. Mol. Biol. Cell 16, 1593-605, (2005). View articlePMID: 15659643

3.Mitophagy in yeast occurs through a selective mechanism. Kanki T, Klionsky DJ. J. Biol. Chem. 283, 32386-93, (2008). View articlePMID: 18818209

4.Recruitment of Atg9 to the preautophagosomal structure by Atg11 is essential for selective autophagy in budding yeast. He C, Song H, Yorimitsu T, Monastyrska I, Yen WL, Legakis JE, Klionsky DJ. J. Cell Biol. 175, 925-35, (2006). View articlePMID: 17178909

5.p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200. Morselli E, Shen S, Ruckenstuhl C, Bauer MA, Marino G, Galluzzi L, Criollo A, Michaud M, Maiuri MC, Chano T, Madeo F, Kroemer G. Cell Cycle 10, 2763-9, (2011). View articlePMID: 21775823

6.Schizosaccharomyces pombe taf1+ is required for nitrogen starvation-induced sexual development and for entering the dormant GO state. Ueno M, Kurokawa R, Renauld H, Watanabe K, Ushimaru T, Uritani M, Yoshinaga K, Hiraoka Y. Curr. Genet. 38, 307-13, (2001). View articlePMID: 11270572

GO terms

molecular function

  • None

cellular component

  • None
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