F
IPR040191

U3 small nucleolar RNA-associated protein 10

InterPro entry
Short nameUTP10

Description

Proteins in this entry contain an armadillo-type fold, and a BP28, C-terminal domain. This entry includes U3 small nucleolar RNA-associated protein 10 (Utp10), which is a HEAT-repeat containing protein involved in nucleolar processing of pre-18S ribosomal RNA
[3]
. Utp10 is also involved in 40S ribosome maturation
[1]
. This entry also includes HEAT repeat-containing protein 1 (HEATR1) from humans. HEATR1 is required for optimal pre-ribosomal RNA transcription by RNA polymerase I
[2]
.

References

1.Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation. Dez C, Dlakic M, Tollervey D. RNA 13, 1516-27, (2007). View articlePMID: 17652137

2.Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells. Prieto JL, McStay B. Genes Dev. 21, 2041-54, (2007). View articlePMID: 17699751

3.A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis. Dragon F, Gallagher JE, Compagnone-Post PA, Mitchell BM, Porwancher KA, Wehner KA, Wormsley S, Settlage RE, Shabanowitz J, Osheim Y, Beyer AL, Hunt DF, Baserga SJ. Nature 417, 967-70, (2002). View articlePMID: 12068309

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