F
IPR040322

RNA-binding protein RO60

InterPro entry
Short nameTROVE2
Overlapping
homologous
superfamilies
 

Description

Proteins in this family contain a TROVE (Telomerase, Ro and Vault) domain and include RNA-binding protein RO60 (TROVE2), an RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs
[2, 1]
.

References

1.The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression. Hung T, Pratt GA, Sundararaman B, Townsend MJ, Chaivorapol C, Bhangale T, Graham RR, Ortmann W, Criswell LA, Yeo GW, Behrens TW. Science 350, 455-9, (2015). PMID: 26382853

2.Human Y5 RNA specializes a Ro ribonucleoprotein for 5S ribosomal RNA quality control. Hogg JR, Collins K. Genes Dev. 21, 3067-72, (2007). View articlePMID: 18056422

GO terms

biological process

  • None

molecular function

cellular component

  • None
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