D
IPR040793

CDH1/2, SANT-Helical linker 1

InterPro entry
Short nameCDH1_2_SANT_HL1

Description

CDH1 is an ATP-dependent chromatin-remodelling factor and plays an important role in regulating nucleosome assembly and mobilization. CHD1 consists of double chromodomain, SNF2-related ATPase domain, and a C-terminal DNA-binding domain. The DNA-binding domain contains SANT (Swi3, Ada2, N-CoR, TFIIIB) and SLIDE (SANT-like ISWI) domains in its C-terminal region
[1]
. SANT domains are structurally related to Myb-like domains are common motifs found in chromatin interacting proteins. Deletion of individual SANT or SLIDE domains in CDH1 does not significantly affect nucleosome binding, but combined deletion of both domains severely compromise binding, suggesting that the SANT-SLIDE motif recognizes DNA/nucleosomes as a single cooperative unit. SANT sequences of Chd1 proteins are the most distantly relation group of sequences relation to other SANT/Myb sequences, and are more diverse than other SANT proteins
[2]
. The SANT and SLIDE regions are well conserved in both Chd1 and ISWI (imitation switch) remodelling enzymes
[3]
. This domain comprises the SANT region and the helical linker region 1 (HL1).

References

1.Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1. Qin S, Liu Y, Tempel W, Eram MS, Bian C, Liu K, Senisterra G, Crombet L, Vedadi M, Min J. Nat Commun 5, 3952, (2014). View articlePMID: 24853335

2.The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains. Ryan DP, Sundaramoorthy R, Martin D, Singh V, Owen-Hughes T. EMBO J. 30, 2596-609, (2011). View articlePMID: 21623345

3.The Chromatin Remodelling Protein CHD1 Contains a Previously Unrecognised C-Terminal Helical Domain. Mohanty B, Helder S, Silva AP, Mackay JP, Ryan DP. J. Mol. Biol. 428, 4298-4314, (2016). View articlePMID: 27591891

Cross References

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