H
IPR041899

MAGE homology domain, winged helix WH2 motif

InterPro entry
Short nameMAGE_WH2
Overlapping entries
 

Description

This superfamily includes MAGE (melanoma antigen-encoding gene) proteins, which are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function is currently unknown. This superfamily also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex and interacts with NSE4/EID family proteins
[2, 1]
. Nse3 has been demonstrated to be important in meiosis
[3]
.

MAGE proteins share a conserved domain known as the MAGE homology domain (MHD). This superfamily entry represents the domain that contains a winged helix motif WH2.

References

1.Analysis of the Nse3/MAGE-binding domain of the Nse4/EID family proteins. Guerineau M, Kriz Z, Kozakova L, Bednarova K, Janos P, Palecek J. PLoS ONE 7, e35813, (2012). View articlePMID: 22536443

2.Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID Families. Hudson JJ, Bednarova K, Kozakova L, Liao C, Guerineau M, Colnaghi R, Vidot S, Marek J, Bathula SR, Lehmann AR, Palecek J. PLoS ONE 6, e17270, (2011). View articlePMID: 21364888

3.Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis. Pebernard S, McDonald WH, Pavlova Y, Yates JR 3rd, Boddy MN. Mol. Biol. Cell 15, 4866-76, (2004). View articlePMID: 15331764

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