D
IPR041992

SMCT1, solute-binding domain

InterPro entry
Short nameSLC5sbd_SMCT1
Overlapping
homologous
superfamilies
 

Description

This entry represents the solute-binding domain of SMCT1.

SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide
[4, 6]
. The expression of human SMCT1 is under the control of the C/EBP transcription factor. Its tumour-suppressive role is related to uptake of butyrate, propionate, and pyruvate, these latter are inhibitors of histone deacetylases. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs
[2]
. SMCT1 also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and through transporting l-lactate and ketone bodies helps maintain the energy status and the function of neurons
[5, 1]
. In the kidney its expression is limited to the S3 segment of the proximal convoluted tubule (in contrast to the low-affinity monocarboxylate transporter SMCT2, belonging to a different family, which is expressed along the entire length of the tubule). In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT1 is expressed predominantly in retinal neurons and in retinal pigmented epithelial (RPE) cells
[3]
.

References

1.Identity of SMCT1 (SLC5A8) as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain. Martin PM, Gopal E, Ananth S, Zhuang L, Itagaki S, Prasad BM, Smith SB, Prasad PD, Ganapathy V. J. Neurochem. 98, 279-88, (2006). View articlePMID: 16805814

2.Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract. Gopal E, Miyauchi S, Martin PM, Ananth S, Roon P, Smith SB, Ganapathy V. Pharm. Res. 24, 575-84, (2007). View articlePMID: 17245649

3.Expression of the sodium-coupled monocarboxylate transporters SMCT1 (SLC5A8) and SMCT2 (SLC5A12) in retina. Martin PM, Dun Y, Mysona B, Ananth S, Roon P, Smith SB, Ganapathy V. Invest. Ophthalmol. Vis. Sci. 48, 3356-63, (2007). View articlePMID: 17591909

4.Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter. Miyauchi S, Gopal E, Babu E, Srinivas SR, Kubo Y, Umapathy NS, Thakkar SV, Ganapathy V, Prasad PD. Biochim. Biophys. Acta 1798, 1164-71, (2010). View articlePMID: 20211600

5.Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes. Rodriguez AM, Perron B, Lacroix L, Caillou B, Leblanc G, Schlumberger M, Bidart JM, Pourcher T. J. Clin. Endocrinol. Metab. 87, 3500-3, (2002). View articlePMID: 12107270

6.Biology of human sodium glucose transporters. Wright EM, Loo DD, Hirayama BA. Physiol. Rev. 91, 733-94, (2011). View articlePMID: 21527736

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