IPR041997
Large ribosomal subunit protein eL6, KOW domain
InterPro entry
Short name | Ribosomal_eL6_KOW |
Overlapping homologous superfamilies |
Description
Large ribosomal subunit protein eL6 (RPL6) contains a KOW motif and has an extra ribosomal role regulating the DNA damage response
[2]. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4
[1].
References
1.KOW: a novel motif linking a bacterial transcription factor with ribosomal proteins. Kyrpides NC, Woese CR, Ouzounis CA. Trends Biochem. Sci. 21, 425-6, (1996). View articlePMID: 8987397
2.Ribosomal protein L6 (RPL6) is recruited to DNA damage sites in a poly (ADP-ribose) polymerase-dependent manner and regulates the DNA damage response. Yang C, Zang W, Ji Y, Li T, Yang Y, Zheng X. J. Biol. Chem. (2018). View articlePMID: 30598506
Contributing Member Database Entry
- CDD:cd13156
Representative structure
8ccs: 80S S. cerevisiae ribosome with ligands in hybrid-1 pre-translocation (PRE-H1) complex