D
IPR042060

Polycystin-1 like, PLAT/LH2 domain

InterPro entry
Short namePLAT_polycystin1
Overlapping
homologous
superfamilies
 
domain relationships

Description

This is the PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD)
[2, 3, 4, 5]
. The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins
[1]
.

References

1.The PLAT domain: a new piece in the PKD1 puzzle. Bateman A, Sandford R. Curr. Biol. 9, R588-90, (1999). View articlePMID: 10469604

2.Polycystins, calcium signaling, and human diseases. Delmas P, Padilla F, Osorio N, Coste B, Raoux M, Crest M. Biochem. Biophys. Res. Commun. 322, 1374-83, (2004). View articlePMID: 15336986

3.Molecular basis of autosomal-dominant polycystic kidney disease. Gallagher AR, Hidaka S, Gretz N, Witzgall R. Cell. Mol. Life Sci. 59, 682-93, (2002). View articlePMID: 12022474

4.Polycystin: new aspects of structure, function, and regulation. Wilson PD. J. Am. Soc. Nephrol. 12, 834-45, (2001). PMID: 11274246

5.Polycystins: from mechanosensation to gene regulation. Delmas P. Cell 118, 145-8, (2004). View articlePMID: 15260985

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