H
IPR042194

FHIPEP, domain 1

InterPro entry
Short nameFHIPEP_1
Overlapping entries
 

Description

The Flagellar/Hr/Invasion Proteins Export Pore (FHIPEP) family
[3, 1]
consists of a number of proteins that constitute the type III secretion (or signal peptide-independent) pathway apparatus
[2, 4]
. This mechanism translocates proteins lacking an N-terminal signal peptide across the cell membrane in one step, as it does not require an intermediate periplasmic process to cleave the signal peptide. It is a common pathway amongst Gram-negative bacteria for secreting toxic and flagellar proteins.

This superfamily represents the domain 1 found in FHIPEP protein.

References

1.Homology between the HrpO protein of Pseudomonas solanacearum and bacterial proteins implicated in a signal peptide-independent secretion mechanism. Gough CL, Genin S, Lopes V, Boucher CA. Mol. Gen. Genet. 239, 378-92, (1993). View articlePMID: 8316211

2.Secretion across the bacterial outer membrane. Wandersman C. Trends Genet. 8, 317-22, (1992). View articlePMID: 1365398

3.HrpI of Erwinia amylovora functions in secretion of harpin and is a member of a new protein family. Wei ZM, Beer SV. J. Bacteriol. 175, 7958-67, (1993). View articlePMID: 8253684

4.Determinants of extracellular protein secretion in gram-negative bacteria. Lory S. J. Bacteriol. 174, 3423-8, (1992). View articlePMID: 1592799

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