H
IPR042296

tRNA methyltransferase, Trm1, C-terminal

InterPro entry
Short nametRNA_met_Trm1_C
Overlapping entries
 

Description

Trm1 (
2.1.1.216
) dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups
[2, 1]
. In Saccharomyces cerevisiae, Trm1 is required for the modification of both mitochondrial and cytoplasmic tRNAs
[3]
. This family also includes the related TRMT1-like protein from Mus musculus, which may play a role in motor coordination and exploratory behaviour
[5]
, and similar mammal sequences.

This superfamily represents the C terminus of Trm1. This domain is characterised by the presence zinc-cysteine cluster where a zinc atom is bound to four cysteine residues and functions as a structural element that holds the tRNA-binding site between the N- and C-terminal domains
[4]
.

References

1.Characterisation and enzymatic properties of tRNA(guanine 26, N (2), N (2))-dimethyltransferase (Trm1p) from Pyrococcus furiosus. Constantinesco F, Motorin Y, Grosjean H. J. Mol. Biol. 291, 375-92, (1999). View articlePMID: 10438627

2.The tRNA(guanine-26,N2-N2) methyltransferase (Trm1) from the hyperthermophilic archaeon Pyrococcus furiosus: cloning, sequencing of the gene and its expression in Escherichia coli. Constantinesco F, Benachenhou N, Motorin Y, Grosjean H. Nucleic Acids Res. 26, 3753-61, (1998). View articlePMID: 9685492

3.Isolation and characterization of the TRM1 locus, a gene essential for the N2,N2-dimethylguanosine modification of both mitochondrial and cytoplasmic tRNA in Saccharomyces cerevisiae. Ellis SR, Morales MJ, Li JM, Hopper AK, Martin NC. J. Biol. Chem. 261, 9703-9, (1986). PMID: 2426253

4.Crystal structure of tRNA N2,N2-guanosine dimethyltransferase Trm1 from Pyrococcus horikoshii. Ihsanawati, Nishimoto M, Higashijima K, Shirouzu M, Grosjean H, Bessho Y, Yokoyama S. J. Mol. Biol. 383, 871-84, (2008). View articlePMID: 18789948

5.The mouse Trm1-like gene is expressed in neural tissues and plays a role in motor coordination and exploratory behaviour. Vauti F, Goller T, Beine R, Becker L, Klopstock T, Holter SM, Wurst W, Fuchs H, Gailus-Durner V, de Angelis MH, Arnold HH. Gene 389, 174-85, (2007). View articlePMID: 17198746

Cross References

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