F
IPR042433

Allograft inflammatory factor 1

InterPro entry
Short nameAIF1/AIF1L
Overlapping
homologous
superfamilies
 

Description

This entry includes AIF1 (also know as Iba1, ionized calcium-binding adapter molecule 1) and AIF1L (Iba2) from humans. They are actin-binding proteins
[2]
. AIF1 has been shown to promote vascular smooth muscle cell migration
[3]
. AIF1L is involved in the stabilization of podocyte morphology by titrating actomyosin contractility and membrane dynamics
[1]
.

This entry also includes calcium-binding protein B from Dictyostelium discoideum.

References

1.AIF1L regulates actomyosin contractility and filopodial extensions in human podocytes. Yasuda-Yamahara M, Rogg M, Yamahara K, Maier JI, Huber TB, Schell C. PLoS ONE 13, e0200487, (2018). PMID: 30001384

2.Structural and functional characterization of human Iba proteins. Schulze JO, Quedenau C, Roske Y, Adam T, Schuler H, Behlke J, Turnbull AP, Sievert V, Scheich C, Mueller U, Heinemann U, Bussow K. FEBS J. 275, 4627-40, (2008). View articlePMID: 18699778

3.AIF-1 is an actin-polymerizing and Rac1-activating protein that promotes vascular smooth muscle cell migration. Autieri MV, Kelemen SE, Wendt KW. Circ. Res. 92, 1107-14, (2003). PMID: 12714565

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