IPR042490
Acyl-CoA thioester hydrolase/BAAT, N-terminal
InterPro entry
Short name | Thio_Ohase/BAAT_N |
Overlapping entries |
Description
This superfamily represents the N-terminal region of the acyl-CoA thioester hydrolase and bile acid-CoA:amino acid N-acetyltransferase (BAAT)
[1]. This region is not thought to contain the active site of either enzyme. Thioesterase isoforms have been identified in peroxisomes, cytoplasm and mitochondria, and are likely to have distinct functions in lipid metabolism
[2]. The N-terminal domain contains a seven-stranded β-sandwich, which has some distant structural homologs in other proteins
[3].
References
1.Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism. Hunt MC, Solaas K, Kase BF, Alexson SE. J. Biol. Chem. 277, 1128-38, (2002). View articlePMID: 11673457
2.Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism. Hunt MC, Nousiainen SE, Huttunen MK, Orii KE, Svensson LT, Alexson SE. J. Biol. Chem. 274, 34317-26, (1999). View articlePMID: 10567408
3.Crystal structure of human mitochondrial acyl-CoA thioesterase (ACOT2). Mandel CR, Tweel B, Tong L. Biochem. Biophys. Res. Commun. 385, 630-3, (2009). View articlePMID: 19497300
Cross References
Contributing Member Database Entry
- CATH-Gene3D:G3DSA:2.60.40.2240