IPR042550
M matrix/glycoprotein, gammacoronavirus
InterPro entry
Short name | GAMMA_CORONA_M |
family relationships |
Description
This family consists of various Gammacoronavirus matrix proteins which are transmembrane glycoproteins.
M proteins play a critical role in protein-protein interactions (as well as protein-RNA interactions) since virus-like particle (VLP) formation in many coronavirus requires only the M and envelope (E) proteins for efficient virion assembly
[1]. The M protein or E1 glycoprotein is implicated in virus assembly
[3]. The E1 viral membrane protein is required for formation of the viral envelope and is transported via the Golgi complex
[2].
References
1.Incorporation of spike and membrane glycoproteins into coronavirus virions. Ujike M, Taguchi F. Viruses 7, 1700-25, (2015). PMID: 25855243
2.Sequence analysis of the membrane protein gene of human coronavirus 229E. Jouvenne P, Richardson CD, Schreiber SS, Lai MM, Talbot PJ. Virology 174, 608-12, (1990). View articlePMID: 2305554
3.Sequence and topology of a model intracellular membrane protein, E1 glycoprotein, from a coronavirus. Armstrong J, Niemann H, Smeekens S, Rottier P, Warren G. Nature 308, 751-2, (1984). View articlePMID: 6325918