F
IPR042550

M matrix/glycoprotein, gammacoronavirus

InterPro entry
Short nameGAMMA_CORONA_M
family relationships

Description

This family consists of various Gammacoronavirus matrix proteins which are transmembrane glycoproteins.

M proteins play a critical role in protein-protein interactions (as well as protein-RNA interactions) since virus-like particle (VLP) formation in many coronavirus requires only the M and envelope (E) proteins for efficient virion assembly
[1]
. The M protein or E1 glycoprotein is implicated in virus assembly
[3]
. The E1 viral membrane protein is required for formation of the viral envelope and is transported via the Golgi complex
[2]
.

References

1.Incorporation of spike and membrane glycoproteins into coronavirus virions. Ujike M, Taguchi F. Viruses 7, 1700-25, (2015). PMID: 25855243

2.Sequence analysis of the membrane protein gene of human coronavirus 229E. Jouvenne P, Richardson CD, Schreiber SS, Lai MM, Talbot PJ. Virology 174, 608-12, (1990). View articlePMID: 2305554

3.Sequence and topology of a model intracellular membrane protein, E1 glycoprotein, from a coronavirus. Armstrong J, Niemann H, Smeekens S, Rottier P, Warren G. Nature 308, 751-2, (1984). View articlePMID: 6325918

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