H
IPR043047

Hri1, N-terminal domain superfamily

InterPro entry
Short nameHri1_N_sf
Overlapping entries
 
Hri1, N-terminal (IPR038744)
Protein Hri1 (IPR031818)

Description

This superfamily represents the N-terminal domain of Saccharomyces cerevisiae's Hri1 (Hrr25-interacting protein 1, YLR301w), a non-essential protein named for its interaction with the yeast protein kinase Hrr25. It has also been shown to interact with Sec72p, although it does not seem to be involved in protein translocation into the ER. This N-terminal domain of Hri1p contains a tandem repeat of a structural unit that forms a β-barrel with structural similarity to nitrobindin. It is involved in homodimerization and it may also contain a ligand binding site
[2, 3, 1]
.

References

1.Novel β-structure of YLR301w from Saccharomyces cerevisiae. Kim KH, Ahn HJ, Lee WK, Lee C, Yu MH, Kim EE. Acta Crystallogr. D Biol. Crystallogr. 68, 531-40, (2012). View articlePMID: 22525751

2.Identification of novel protein-protein interactions at the cytosolic surface of the Sec63 complex in the yeast ER membrane. Willer M, Jermy AJ, Young BP, Stirling CJ. Yeast 20, 133-48, (2003). View articlePMID: 12518317

3.Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes. Fasolo J, Sboner A, Sun MG, Yu H, Chen R, Sharon D, Kim PM, Gerstein M, Snyder M. Genes Dev. 25, 767-78, (2011). View articlePMID: 21460040

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