IPR043137
Gamma-glutamyltranspeptidase, small subunit
InterPro entry
Short name | GGT_ssub |
Overlapping entries |
Description
This entry represents the small subunit of GGT.
Gamma-glutamyltranspeptidase (
2.3.2.2) (GGT)
[1] is a heterodimeric enzyme that is generated from the precursor protein through post-translational processing, and catalyses the hydrolysis of gamma-glutamyl bonds in gamma-glutamyl compounds. GGT has a stacked α-β-β-α fold comprising the large and small subunits, similar to the folds seen in members of the N-terminal nucleophile hydrolase superfamily
[2].
References
1.gamma-Glutamyl transpeptidase from kidney. Tate SS, Meister A. Meth. Enzymol. 113, 400-19, (1985). View articlePMID: 2868390
2.Crystal structures of gamma-glutamyltranspeptidase from Escherichia coli, a key enzyme in glutathione metabolism, and its reaction intermediate. Okada T, Suzuki H, Wada K, Kumagai H, Fukuyama K. Proc. Natl. Acad. Sci. U.S.A. 103, 6471-6, (2006). View articlePMID: 16618936
Cross References
Contributing Member Database Entry
- CATH-Gene3D:G3DSA:3.60.20.40
Representative structure
7ld9: Structure of human GGT1 in complex with ABBA