H
IPR043137

Gamma-glutamyltranspeptidase, small subunit

InterPro entry
Short nameGGT_ssub
Overlapping entries
 

Description

This entry represents the small subunit of GGT.

Gamma-glutamyltranspeptidase (
2.3.2.2
) (GGT)
[1]
is a heterodimeric enzyme that is generated from the precursor protein through post-translational processing, and catalyses the hydrolysis of gamma-glutamyl bonds in gamma-glutamyl compounds. GGT has a stacked α-β-β-α fold comprising the large and small subunits, similar to the folds seen in members of the N-terminal nucleophile hydrolase superfamily
[2]
.

References

1.gamma-Glutamyl transpeptidase from kidney. Tate SS, Meister A. Meth. Enzymol. 113, 400-19, (1985). View articlePMID: 2868390

2.Crystal structures of gamma-glutamyltranspeptidase from Escherichia coli, a key enzyme in glutathione metabolism, and its reaction intermediate. Okada T, Suzuki H, Wada K, Kumagai H, Fukuyama K. Proc. Natl. Acad. Sci. U.S.A. 103, 6471-6, (2006). View articlePMID: 16618936

Cross References

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