IPR043360
PP2B
InterPro entry
Short name | PP2B |
Overlapping homologous superfamilies |
Description
PP2B (calcineurin) is a unique serine/threonine protein phosphatase in its regulation by a second messenger (calcium acting via calmodulin)
[3, 2]. PP2B is involved in many biological processes including immune responses, the second messenger cAMP pathway, sodium/potassium ion transport in the nephron, cell cycle progression in lower eukaryotes, cardiac hypertrophy and memory formation. PP2B is highly conserved from yeast to humans, but is absent from plants. PP2B is a heterodimer consisting of a catalytic subunit (CnA) and a regulatory subunit (CnB); CnB contains four Ca2 binding motifs referred to as EF hands
[1].
References
1.A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants. Rodriguez A, Roy J, Martinez-Martinez S, Lopez-Maderuelo MD, Nino-Moreno P, Orti L, Pantoja-Uceda D, Pineda-Lucena A, Cyert MS, Redondo JM. Mol. Cell 33, 616-26, (2009). View articlePMID: 19285944
GO terms
biological process
molecular function
cellular component
- None
Cross References
ENZYME
Contributing Member Database Entry
- PANTHER:PTHR45673
Representative structure
3ll8: Crystal Structure of Calcineurin in Complex with AKAP79 Peptide