F
IPR043360

PP2B

InterPro entry
Short namePP2B
Overlapping
homologous
superfamilies
 

Description

PP2B (calcineurin) is a unique serine/threonine protein phosphatase in its regulation by a second messenger (calcium acting via calmodulin)
[3, 2]
. PP2B is involved in many biological processes including immune responses, the second messenger cAMP pathway, sodium/potassium ion transport in the nephron, cell cycle progression in lower eukaryotes, cardiac hypertrophy and memory formation. PP2B is highly conserved from yeast to humans, but is absent from plants. PP2B is a heterodimer consisting of a catalytic subunit (CnA) and a regulatory subunit (CnB); CnB contains four Ca2 binding motifs referred to as EF hands
[1]
.

References

1.A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants. Rodriguez A, Roy J, Martinez-Martinez S, Lopez-Maderuelo MD, Nino-Moreno P, Orti L, Pantoja-Uceda D, Pineda-Lucena A, Cyert MS, Redondo JM. Mol. Cell 33, 616-26, (2009). View articlePMID: 19285944

2.Regulation of the phosphatase PP2B by protein-protein interactions. Nygren PJ, Scott JD. Biochem. Soc. Trans. 44, 1313-1319, (2016). PMID: 27911714

3.Protein phosphatases and calcium/calmodulin-dependent protein kinase II-dependent synaptic plasticity. Colbran RJ. J. Neurosci. 24, 8404-9, (2004). PMID: 15456812

GO terms

Cross References

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