IPR043662
NAD-protein ADP-ribosyltransferase ModB-like
InterPro entry
Short name | ModB-like |
Description
Bacteriophage T4 encodes three ADP-ribosyltransferases: Alt, ModA, and ModB. The ADP-ribosylating activity of each is directed to a specific set of host proteins. ModB ADP-ribosylates a number of host proteins including ribosomal protein S1
[1].
Protein ADP-ribosylation is an important posttranslational modification catalyzed by a group of enzymes known as ADP-ribosyltransferases (ADP-RTs)
[3]. ADP-RTs transfer single or multiple ADP-ribose moieties from NAD to a specific amino acid residue within a target protein, forming mono ADP-ribosylation or poly ADP-ribosylation (PARylation)
[3]. ADP-ribosylation changes the electrostatic potential of a target protein by introducing two phosphate groups and may affect protein-DNA as well as protein-protein interactions
[2]. Protein ADP-ribosylation plays versatile roles in multiple biological processes.
References
1.The mono-ADP-ribosyltransferases Alt and ModB of bacteriophage T4: target proteins identified. Depping R, Lohaus C, Meyer HE, Ruger W. Biochem. Biophys. Res. Commun. 335, 1217-23, (2005). PMID: 16112649
GO terms
biological process
- None
molecular function
cellular component
- None
Cross References
ENZYME
Contributing Member Database Entry
- HAMAP:MF_04142