F
IPR043662

NAD-protein ADP-ribosyltransferase ModB-like

InterPro entry
Short nameModB-like

Description

This entry represents a family of NAD-protein ADP-ribosyltransferases mostly from Myoviridae, incluidng ModB from the bacteriophage T4
[1, 2]
.

Bacteriophage T4 encodes three ADP-ribosyltransferases: Alt, ModA, and ModB. The ADP-ribosylating activity of each is directed to a specific set of host proteins. ModB ADP-ribosylates a number of host proteins including ribosomal protein S1
[1]
.

Protein ADP-ribosylation is an important posttranslational modification catalyzed by a group of enzymes known as ADP-ribosyltransferases (ADP-RTs)
[3]
. ADP-RTs transfer single or multiple ADP-ribose moieties from NAD to a specific amino acid residue within a target protein, forming mono ADP-ribosylation or poly ADP-ribosylation (PARylation)
[3]
. ADP-ribosylation changes the electrostatic potential of a target protein by introducing two phosphate groups and may affect protein-DNA as well as protein-protein interactions
[2]
. Protein ADP-ribosylation plays versatile roles in multiple biological processes.

References

1.The mono-ADP-ribosyltransferases Alt and ModB of bacteriophage T4: target proteins identified. Depping R, Lohaus C, Meyer HE, Ruger W. Biochem. Biophys. Res. Commun. 335, 1217-23, (2005). PMID: 16112649

2.ModA and ModB, two ADP-ribosyltransferases encoded by bacteriophage T4: catalytic properties and mutation analysis. Tiemann B, Depping R, Gineikiene E, Kaliniene L, Nivinskas R, Ruger W. J. Bacteriol. 186, 7262-72, (2004). PMID: 15489438

3.ADP-ribosyltransferases and poly ADP-ribosylation. Liu C, Yu X. Curr. Protein Pept. Sci. 16, 491-501, (2015). PMID: 25938242

GO terms

biological process

  • None

cellular component

  • None

Cross References

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